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KMID : 0351819980390020133
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Kyunpook University Medical Journal
1998 Volume.39 No. 2 p.133 ~ p.146
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Analysis of the lupus band test in patients with lupus erythematosus over 15years(1982~1997)
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Chung Sang-Lip
Kwon Soon-Baek
Kim Do-Won
Jun Jae-Bok
Lee Seok-Jong
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Abstract
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The lupus band test(LB"I) has been proposed as a diagnostic test for lupus erythematosus(LE), differentiating discoid lupus erythematosus(DLE) from systemic lupus erythematosus(SLE). And nonlesional LBT in patients with SLE has been known to have value for implying activity and prognosis of the disease, but there has been also some controversy on the results between the authors.
The propose of this study was to evaluate the incidence of a positive LBT in patients with LE and its relationship with different clinical manifestations and different laboratory findings, respectively, in patients with SLE. Direct immunofluorescence studies ~Nas done with biopsies taken from - involved(lesional) skin in 25 patients with DLE, and from involved, uninvolved(nonlesional)-exposed and rorinolved-nonexposed skin in 60 patients with SLE.
The results are as follows:
1. The incidence of a positive LBT in patients with DLE was 80%, and IgG was most frequently deposited(56%), whereas IgA was least frequently deposited(16r6).
2. The incidence of a positive LBT in patients with SLE was 88% in involved skin, 84% in : uninvolved-exposed skin, and 55% in uninvolved-nonexposed skin, respectively. IgM was most frequently deposited, whereas IgA was least frequently deposited in both I~esional and nonlesional skin.
3. The incidence of a positive LBT of involved, uninvolved-exposed, and runinvolved-nonexposed skin in patients with SLE showed no significant difference by different clinical manifestations and different laboratory findings, respectively.
4. A positive LBT composed of IgG alone or IgG and other Igs were associated with higher incidence of anemia, increased ESR, ANA, anti-DNA than a positive LBT composed of IgM alone in both lesional and nonlesional skin of patients with SLE. And it was also associated with higher incidence of renal involvement in uninvolved-nonexposed slain.
5. 23 renal biopsies in patients with SLE showed diffuse proliferative glomerulonephritis in 11(48%), membranous glomerulonephritis in 8(3~%), and focal -segmental glomerulonephritis in 4(17%). And there was no significant relationship between histopathologic type of nephritis and the results of lupus band test.
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KEYWORD
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Lupus band test, Lupus erythematosus
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